Instructor Profile:
Dr. Shilpi Shrivastava
Dr. Shilpi Shrivastava, a distinguished academician holding the position of Professor and Head of the Department of Chemistry at Kalinga University in Naya Raipur, India (492101). With an illustrious career spanning over 24 years, Dr. Shrivastava is not only a seasoned educator but also an accomplished administrator within the higher education sector. Armed with a Ph.D. in Chemistry, an M.Phil. in Chemistry, and an M.Sc. in Applied Chemistry, her academic credentials reflect a profound understanding of the subject.
Dr. Shrivastava’s contributions extend beyond the classroom, encompassing a prolific research portfolio. She has authored a substantial body of scholarly articles, delivered invited lectures, and served as an external examiner for Ph.D. Viva examinations at various government universities. In her role as the Examination Center Superintendent at Kalinga University, she has showcased administrative acumen.
Recognized for her academic excellence, Dr. Shrivastava has received esteemed accolades and actively participates in conferences and workshops, contributing to the academic discourse. Her research endeavors focus on advancing sustainability and well-being within the realms of chemistry and environmental science. A prolific author, she has published numerous research papers, books, book chapters, and patents, showcasing her commitment to advancing knowledge in her field.
One of Dr. Shrivastava’s key areas of expertise lies in medicinal chemistry, a field involving the identification, synthesis, and development of chemical entities for therapeutic use. Her research delves into the study of existing drugs, their biological properties, and quantitative structure-activity relationships (QSAR), contributing significantly to the field.
Glimpse of Instructor Background
Educational Background:
- D. in Chemistry
- Phil. in Chemistry
- Sc. in Applied Chemistry
- Ed B.Sc. in ZBC
Areas of Specialization:
- Medicinal Chemistry: Expertise in the identification, synthesis, and development of new chemical entities for therapeutic use.
- Study of existing drugs, their biological properties, and quantitative structure-activity relationships (QSAR).
Professional Experience:
- Shrivastava’s rich academic career includes roles as a professor, and she currently heads the Department of Chemistry at Kalinga University.
Recent Achievements:
- Currently serving as the Head of the Department of Chemistry at Kalinga University.
- Held the position of Examination Center Superintendent at Kalinga University.
Research Contributions:
- Authored numerous scholarly articles, research papers, books, book chapters, and patents.
- Actively engaged in impactful research contributing to the advancement of sustainability and well-being in the fields of chemistry and environmental science.
Professional Achievements:
- External Examiner for Ph.D. Viva examinations at multiple government universities.
- Invited lecturer at various conferences and workshops.
Awards and Recognition:
- Honoured with esteemed accolades for outstanding contributions to academia.
Module-wise course content: Medicinal Chemistry
Module 1: Foundations of Drug Design and Chiral Drugs
- Understanding Drug Design: Introduction to the drug development process, procedures, lead compounds, lead modification, prodrugs, soft drugs, and structure-activity relationship (SAR). Theories of drug activity, including occupancy theory, rate theory, induced fit theory, and concepts of drug receptors.
- Pharmacokinetics: Exploring drug absorption, disposition, elimination, and key pharmacokinetic parameters. The role of pharmacokinetics in drug development processes.
- Pharmacodynamics: Introduction to enzyme stimulation, inhibition, membrane active drugs, drug metabolism, xenobiotics, and the significance of drug metabolism in medicinal chemistry.
- Chiral Drugs: Comprehensive study of chiral drugs, including eutomer, distomer, eudesmic ratio, synthesis, and pharmacological activity. Exploration of chiral templates, chirons, and their utilization in retrosynthetic strategy and synthesis.
Module 2: Antibiotics, Drug Targets, and Antineoplastic Agents
- Antibiotics: Understanding cell wall biosynthesis inhibitors, δ-lactam rings, and antibiotics inhibiting protein synthesis. Synthesis of penicillin-G, penicillin-V, ampicillin, amoxycillin, chloramphenicol, cephalosporin, tetracycline, and streptomycin.
- Drug Targets: In-depth exploration of antimicrobial drugs, antifungals, antivirals, anti-protozoals, and antineoplastic agents. Synthesis of mechlorethamine, cyclophosphamide, melphalan, and recent developments in cancer chemotherapy.
- Cardiovascular Drugs: Overview of cardiovascular diseases and the synthesis of drugs affecting peripheral sympathetic function, arteriolar dilators, and specific cardiovascular medications.
- Psychoactive Drugs: Examining neurotransmitters, CNS depressants, general anesthetics, hypnotics, sedatives, anti-anxiety drugs, antipsychotic drugs, antidepressants, and the synthesis of various psychoactive medications.
Module 3: Drug Synthesis and Medicinal Chemistry
- Drugs Based on Substituted Benzene Ring: Synthesis and properties of drugs like chloramphenicol, salmeterol, tolazamide, diclofenac, tiapamil, and amitriptyline.
- Drugs Based on Heterocycles: Exploration of drugs based on five-membered, six-membered, seven-membered, and fused benzene rings. Examples include tolmetin, warfarin, quinine, acyclovir, and methotrexate.
- β-Lactam Antibiotics: In-depth study of penicillin and cephalosporin, along with the introduction of new chemical entities as clinical agents, both synthetic (e.g., ritonavir) and natural (e.g., hamamelitannin).
This comprehensive course encompasses the fundamental principles of drug design, antibiotic synthesis, drug targets, and medicinal chemistry, providing students with a thorough understanding of the field.
